23 days ago
Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion
What's happening
SignalsMonitor is following this as a technology story. Nature is the outlet attached so far. The first report grouped here was at 23 Sept 2026, 16:00 UTC. The headline in use is “Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion”. This note is SignalsMonitor's own briefing, not the publisher's article.
What we know
Nature, Published online: 23 September 2026; doi:10. 1038/s41586-026-11059-5 ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its deletion boosts effector-like states and markedly enhances antiviral and antitumour immunity.
Story timeline
Reports grouped into this story, earliest first. Exact repeats from the same outlet are collapsed.
- First reported by Nature
Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion
Reported by 1 outlet
- Nature